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생명공학대학 - 생명공학대학

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학술지 논문

  • (2016)  Characterization of a family B DNA polymerase from Thermococcus barophilus Ch5 and its application for long and accurate PCR.  ENZYME AND MICROBIAL TECHNOLOGY.  86, 
  • (2016)  Improved PCR performance and fidelity of double mutant Neq A523R/N540R DNA polymerase.  ENZYME AND MICROBIAL TECHNOLOGY.  82, 
  • (2015)  Advanced loop-mediated isothermal amplification method for sensitive and specific detection of Tomato chlorosis virus using a uracil DNA glycosylase to control carry-over contamination.  JOURNAL OF VIROLOGICAL METHODS.  213, 
  • (2014)  Enhanced PCR efficiency of high-fidelity DNA polymerase from Thermococcus waiotapuensis.  ENZYME AND MICROBIAL TECHNOLOGY.  63, 
  • (2014)  Mutations in the palm subdomain of Twa DNA polymerase to enhance PCR efficiency and its function analysis.  JOURNAL OF BIOTECHNOLOGY.  184, 
  • (2014)  Characterization of a Family B DNA Polymerase from the Hyperthermophilic Crenarchaeon Ignicoccus hospitalis KIN4/I and Its Application to PCR.  APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY.  173, 
  • (2014)  Enhancing the processivity of a family B-type DNA polymerase of Thermococcus onnurineus and application to long PCR.  BIOTECHNOLOGY LETTERS.  36,  5
  • (2013)  Broad nucleotide cofactor specificity of DNA ligase from the hyperthermophilic crenarchaeon Hyperthermus butylicus and its evolutionary significance.  EXTREMOPHILES.  17,  3
  • (2013)  Improved PCR performance using mutant Tpa-S DNA polymerases from the hyperthermophilic archaeon Thermococcus pacificus.  JOURNAL OF BIOTECHNOLOGY.  164,  2
  • (2012)  Characterization and PCR application of a new high-fidelity DNA polymerase from Thermococcus waiotapuensis.  ENZYME AND MICROBIAL TECHNOLOGY.  51,  6-7
  • (2012)  Characterization and PCR applications of dUTPase from the hyperthermophilic euryarchaeon Thermococcus pacificus.  ENZYME AND MICROBIAL TECHNOLOGY.  51,  6-7
  • (2011)  Improved thermostability and PCR efficiency of Thermococcus celericrescens DNA polymerase via site-directed mutagenesis.  JOURNAL OF BIOTECHNOLOGY.  155,  2
  • (2011)  Cloning, expression, and PCR application of DNA polymerase from the hyperthermophilic archaeon, Thermococcus celer.  BIOTECHNOLOGY LETTERS.  33,  2
  • (2011)  ‬Among γ-secretase substrates Notch1 alone is sufficient to block neurogenesis but does not confer self-renewal properties to neural stem cells.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.  404,  1
  • (2010)  Purification, crystallization and preliminary crystallographic analysis of a multiple cofactor-dependent DNA ligase from Sulfophobococcus zilligii.  ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS.  66, 
  • (2010)  An amino acid residue in the middle of the fingers subdomain is involved in Neq DNA polymerase processivity: enhanced processivity of engineered Neq DNA polymerase and its PCR application.  PROTEIN ENGINEERING DESIGN & SELECTION.  23,  11
  • (2010)  Characterization and PCR application of a thermostable DNA polymerase from Thermococcus pacificus.  ENZYME AND MICROBIAL TECHNOLOGY.  47, 
  • (2010)  Biochemical Properties and PCR Performance of a Family B DNA Polymerase from Hyperthermophilic Euryarchaeon Thermococcus peptonophilus.  APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY.  160, 
  • (2010)  Molecular and biochemical characterizations of a novel arthropod endo-β-1,3-glucanase from the Antarctic springtail, Cryptopygus antarcticus, horizontally acquired from bacteria.  COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY.  155B,  4
  • (2009)  Production of recombonation single chain antibodies (scFv) in vegetatively reproductive Kalanchoe pinnata by in planta transformation.  PLANT CELL REPORTS.  28,  10

단행본

  • (2003)  현대의 생물공학과 생물산업.  아카데미서적.  공동
  • (2000)  The Cell A Molecular Approach.  도서출판 한우리.  공동

특허/프로그램

  • MUTANT NEQ HS DNA POLYMERASE DERIVED FROM NANOARCHAEUM EQUITANS AND ITS APPLICATION TO HOT-START PCR.  US 14/555,863.  20160826.  미국
  • 나노아케움 이퀴탄스 유래의 Neq HS DNA 중합효소의 돌연변이체 제조 및 이를 이용한 hot-start PCR 응용(Mutant Neq HS DNA polymerases from Nanoarchaeum equitans and its application to hot-start PCR).  제 10-2013-0147812호.  20150123.  대한민국
  • 써모코커스 파시피쿠스 균주 유래의 ＤＮＡ 중합효소 유전자 변이체들 및 이의 이용.  10-2012-0035330.  20130829.  대한민국
  • 써모코커스 와이오타푸엔시스 균주 유래의 DNA 중합효소 변이체들 및 이의 이용.  10-2011-0117309.  20130808.  대한민국
  • 나노아케움 이퀴탄스 ＤＮＡ 중합효소의 단백질 트랜스 스플라이싱을 기반으로 한 핫―스타트 ＰＣＲ 수행방법(HOT-START PCR BASED ON THE PROTEIN TRANS-SPLICING OF NANOARCHAEUM EQUITANS DNA POLYMERASE).  10-1230362-0000.  20130131.  대한민국
  • 나노아케움 이퀴탄스 플러스 DNA 중합효소, 이의제조방법 및 데옥시유티피 (dUTP)와 우라실-DNA 글리코실라제 (UDG)를 이용한 중합효소 연쇄 반응 (PCR) 방법.  2008-0052676.  20120605.  대한민국
  • 써모코커스 마리너스 균주 유래의 내열성 ＤＮＡ 중합효소 및 이의 이용(DNA polymerase derived from Thermococcus marinus and its use).  10-1142950-0000.  20120427.  대한민국
  • 돌연변이 나노아케움 이퀴탄스 Ａ５２３Ｒ ＤＮＡ 중합효소 및 이의 이용(MUTANT NANOARCHAEUM EQUITANS A523R DNA POLYMERASE AND ITS USE).  10-1105271-0000.  20120106.  대한민국
  • Method for preparing active Nanoarchaeum equitans DNA polymerase and the active DNA polymerase prepared by the method.  20060580485.  20100706.  미국
  • 써모코커스 구아이마센시스 균주 유래 내열성 DNA 중합효소 및 이를 이용한 중합효소 연쇄반응 방법.  10-2008-0031585.  20100702.  대한민국
  • 바실러스 스피시스 HJ171 균주 유래의 우라실-DNA 글리코실라제의 제조방법 및 중합효소 연쇄반응에서의 이용.  10-2007-0105238.  20100531.  대한민국
  • Uracil-DNA glycosylase of Psychrobacter sp. HJ147 and use thereof.  11/823,123.  20100525.  미국
  • 사이크로박터 스피시스 HJ147 균주 유래의 우라실-DNA 글리코실라제 및 이의 용도.  2007-0023976.  20090202.  대한민국
  • 돌연변이 DNA 중합효소들 및 그의 유전자들.  10-0844358.  20080701.  대한민국
  • DNA 중합효소 활성증가 단백질 및 이를 암호화하는 유전자.  10-0825279.  20080421.  대한민국
  • 활성형 나노아케움 이퀴탄스의 DNA 중합효소의 제조방법 및 이의 방법으로 제조된 활성형 DNA 중합효소.  10-0793007-0000.  20080102.  대한민국
  • 신규한 우라실-DNA 글리코실라제 (UDG) 및 이의 용도.  10-0787995-0000.  20071214.  대한민국
  • 고호열성 DNA 중합효소 및 이의 제조방법.  10-0777227.  20071112.  대한민국
  • 써모코커스 유래 돌연변이 ＤＮＡ 중합효소들 및 그의유전자들.  10-0777230.  20071112.  대한민국
  • 설포포보코커스 질리지 유래의 내열성 DNA 연결효소.  10-0774102.  20071031.  대한민국

학술회의논문

  • (2015)  Characterization and PCR Application of a Family B DNA Polymerase from Thermococcus sp. CH5.  KMB2015 42nd Ammual Meeting & International Symposium.  대한민국
  • (2015)  Mutant Neq HS DNA Polymerase from Nanoarchaeum equitans and Its Application to Hot-Start PCR.  KMB2015 42nd Ammual Meeting & International Symposium.  대한민국
  • (2015)  Characterization of PI-TCH5-2 Intein Homing Endonuclease Encoded in the DNA Polymerase Gene of Thermococcus sp. CH5.  KMB2015 42nd Ammual Meeting & International Symposium.  대한민국
  • (2015)  Mutational Analysis of Protein Splicing Mediated by the Split Mini-Inteins of Neq DNA Polymerase.  KMB2015 42nd Ammual Meeting & International Symposium.  대한민국
  • (2014)  Enhanced PCR Efficiency of Twa DNA Polymerase by changing His 663 to Arg in the Thumb Domain.  2014 International Symposium and Annual Meeting of The KSABC.  대한민국
  • (2014)  Improved fidelity and PCR performance of Neq DNA polymerase by the A523R/N540R double mutation.  2014 International Symposium and Annual Meeting of The KSABC.  대한민국
  • (2013)  Improved PCR efficiency of Thermococcus waiotapuensis DNA polymerase via site-directed mutagenesis.  2013 International symposium and Annual Meeting of the KSABC.  대한민국
  • (2012)  Characterization and PCR Application of a Family B DNA Polymerase from the Hyperthermophilic Crenarchaeon Ignicoccus hospitalis KIN4/I.  2012 International Symposium and Annual Meeting of the KSABC.  대한민국
  • (2012)  Characterization and PCR application of a new high-fidelity DNA polymerase from Thermococcus waitapuensis.  2012 International Symposium and Annual Meeting of the KSABC.  대한민국
  • (2012)  Enhanced PCR performance of mutant Tpa-S DNA polymerases from the thyperthermophilic archaeon Thermococcus pacificus.  The 9th Asia-Pacific Marine Biotechnology Conference.  일본
  • (2012)  Properties and PCR Applications of dUTPase from Thermococcu pacificus.  The 9th Asia-Pacific Marine Biotechnology Conference.  일본
  • (2011)  Characterization of DNA ligase from the hyperthermophilic crenarchaeon Ignicoccus hospitalis KIN4/I.  2011 International Symposium & Annual Meeting of the KSABC.  대한민국
  • (2011)  Improved PCR performance of a Mutant Tcel B DNA Polymerase from the Hyperthermophilic Archaeon Thermococcus celericrescens.  2011 International Symposium & Annual Meeting of the KSABC.  대한민국
  • (2011)  Unique substrate spectrum and novel hot-start PCR application of Nanoarchaeum equitans family B DNA polymerase.  2011 International Symposium & Annual Meeting of the KSABC.  대한민국
  • (2011)  Cloning, characterization and PCR application of a family B DNA polymerase from Thermococcus celericrescens.  6th Asia-Pacific Biotechnology Congress 40th PSM Annual Convention and Scientific Meeting.  필리핀
  • (2011)  Hot-start PCR based on the protein trans-splicing of Nanoarchaeum equitans DNA polymerase.  6th Asia-Pacific Biotechnology Congress 40th PSM Annual Convention and Scientific Meeting.  필리핀
  • (2010)  Characterization of DNA ligase from the hyperthermophilic crenarchaea Pyrobaculum arsenaticum.  The Commemorative International Symposium for the 50th Ananiversary of KSABC.  대한민국
  • (2010)  PCR performance of the family B DNA polymerase from Thermococcus pacificus improved by the fusion of DNA binding protein.  The Commemorative International Symposium for the 50th Ananiversary of KSABC.  대한민국
  • (2010)  An amino acid residue in the middle of the fingers subdomain is involved in Neq DNA polymerase processivity.  11TH Internayional Symposium on the Genetics of Industrial Microorganisms.  오스트레일리아
  • (2010)  Characterization and PCR application of the thermostable DNA polymerase from Thermococcus pacificus.  11TH Internayional Symposium on the Genetics of Industrial Microorganisms.  오스트레일리아